How we think complex cells evolved Adam Jacobson

What if you could absorb
another organism

and take on its abilities?

Imagine you swallowed a small bird
and suddenly gained the ability to fly.

Or if you engulfed a cobra

and were then able to spit poisonous venom
from your teeth.

Throughout the history of life,

specifically during the evolution
of complex eukaryotic cells,

things like this happened all the time.

One organism absorbed another,

and they united to become a new organism
with the combined abilities of both.

We think that around 2 billion years ago,

the only living organisms on Earth
were prokaryotes,

single-celled organisms
lacking membrane-bound organelles.

Let’s look closely at just three of them.

One was a big, simple blob-like cell

with the ability to absorb things
by wrapping its cell membrane around them.

Another was a bacterial cell

that converted solar energy into sugar
molecules through photosynthesis.

A third used oxygen gas to break down
materials like sugar

and release its energy into a form useful
for life activities.

The blob cells would occasionally absorb
the little photosynthetic bacteria.

These bacteria then lived inside the blob
and divided like they always had,

but their existence became linked.

If you stumbled upon
this living arrangement,

you might just think that the whole thing
was one organism,

that the green photosynthetic bacteria
were just a part of the blob

that performed one of its life functions,

just like your heart is a part of you

that performs the function
of pumping your blood.

This process of cells living together
is called endosymbiosis,

one organism living inside another.

But the endosymbiosis didn’t stop there.

What would happen
if the other bacteria moved in, too?

Now the cells of this species started
becoming highly complex.

They were big and full
of intricate structures

that we call chloroplasts
and mitochondria.

These structures work together
to harness sunlight,

make sugar,

and break down that sugar using the oxygen

that right around this time started
to appear in the Earth’s atmosphere.

Organisms absorbing other organisms

was one way species adapted
to the changing environmental conditions

of their surroundings.

This little story highlights what
biologists call the endosymbiotic theory,

the current best explanation
of how complex cells evolved.

There’s a lot of evidence
that supports this theory,

but let’s look at three main pieces.

First, the chloroplasts and mitochondria
in our cells multiply the very same way

as those ancient bacteria,

which are still around, by the way.

In fact, if you destroy these structures
in a cell, no new ones will appear.

The cell can’t make them.

They can only make more of themselves.

Second piece of evidence.

Chloroplasts and mitochondria both contain
their own DNA and ribosomes.

Their DNA has a circular structure

that is strikingly similar to the DNA
of the ancient bacteria,

and it also contains many similar genes.

The ribosomes, or protein assembly
machines of chloroplasts and mitochondria,

also have the same structure as ribosomes
of ancient bacteria,

but are different from the ribosomes

hanging around
the rest of eukaryotic cell.

Lastly, think about the membranes involved
in the engulfing process.

Chloroplasts and mitochondria
both have two membranes surrounding them,

an inner and outer membrane.

Their inner membrane contains
some particular lipids and proteins

that are not present
in the outer membrane.

Why is that significant?

Because their outer membrane
used to belong to the blob cell.

When they were engulfed
in the endosymbiosis process,

they got wrapped up in that membrane
and kept their own as their inner one.

Surely enough, those same lipids

and proteins are found on the membranes
of the ancient bacteria.

Biologists now use this theory

to explain the origin of the vast
variety of eukaryotic organisms.

Take the green algae that grow on
the walls of swimming pools.

A larger eukaryotic cell with spinning
tail structures, or flagella,

at some point absorbed algae like these
to form what we now call euglena.

Euglena can perform photosynthesis,

break down sugar using oxygen,

and swim around pond water.

And as the theory would predict,

the chloroplasts in these euglena
have three membranes

since they had two before being engulfed.

The absorbing process
of endosymbiotic theory

allowed organisms to combine
powerful abilities

to become better adapted to life on Earth.

The results were species
capable of much more

than when they were separate organisms,

and this was an evolutionary leap

that lead to the microorganisms, plants,

and animals we observe
on the planet today.

如果你能吸收
另一种生物

并发挥它的能力呢?

想象一下,你吞下了一只小鸟
,突然获得了飞行的能力。

或者,如果你吞没了一条眼镜蛇

,然后能够
从你的牙齿中吐出有毒的毒液。

纵观生命史,

特别是在
复杂真核细胞的进化过程中,

这样的事情一直在发生。

一种有机体吸收了另一种有机体

,它们结合成一个
具有两者综合能力的新有机体。

我们认为大约 20 亿年前,

地球上唯一的生物
是原核生物,


缺乏膜结合细胞器的单细胞生物。

让我们仔细看看其中的三个。

一个是一个大而简单的斑点状细胞

,能够
通过将细胞膜包裹在它们周围来吸收物质。

另一种是通过光合作用

将太阳能转化为糖
分子的细菌细胞。

第三个使用氧气分解
糖等物质

并将其能量释放成对
生命活动有用的形式。

斑点细胞偶尔会
吸收小光合细菌。

然后这些细菌生活在斑点内
并像往常一样分裂,

但它们的存在是相互关联的。

如果你偶然发现了
这种生活安排,

你可能会认为整个事物
是一个有机体

,绿色的光合细菌

只是执行其生命功能之一的斑点的一部分,

就像你的心脏是你的一部分

一样 执行
泵送血液的功能。

这种细胞
共生的过程称为内共生,

一个生物体生活在另一个生物体内。

但内共生并没有就此停止。

如果其他细菌也进入会发生什么?

现在这个物种的细胞开始
变得高度复杂。

它们很大,充满

了我们称之为叶绿体
和线粒体的复杂结构。

这些结构
共同利用阳光,

制造糖,

并利用

此时
开始出现在地球大气中的氧气分解糖。

吸收其他生物的生物

是物种
适应周围环境条件变化的一种方式

这个小故事突出了
生物学家所说的内共生理论,

这是目前对
复杂细胞如何进化的最佳解释。

有很多
证据支持这一理论,

但让我们看三个主要部分。

首先,我们细胞中的叶绿体和线粒体
的繁殖方式

那些仍然存在的古老细菌完全相同。

事实上,如果你
在一个细胞中破坏这些结构,就不会出现新的结构。

细胞不能制造它们。

他们只能做更多的自己。

第二个证据。

叶绿体和线粒体都含有
它们自己的 DNA 和核糖体。

它们的DNA呈环状结构

,与古代细菌的DNA惊人地相似

而且还含有许多相似的基因。

核糖体,或
叶绿体和线粒体的蛋白质组装机器,

也与古代细菌的核糖体具有相同的结构

与真核细胞其余部分的核糖体不同。

最后,想想
吞噬过程中涉及的膜。

叶绿体和线粒体
都有两个围绕它们的膜,

一个内膜和一个外膜。

它们的内膜含有
一些在外膜中不存在的特殊脂质和蛋白质

为什么这很重要?

因为它们的外膜
曾经属于斑点细胞。

当它们被吞没
在内共生过程中时,

它们被包裹在那个膜中,
并把它们自己的膜作为它们的内在膜。

毫无疑问,在古代细菌

的细胞膜上也发现了同样的脂质和蛋白质

生物学家现在使用这一理论

来解释
种类繁多的真核生物的起源。

以生长
在游泳池墙壁上的绿藻为例。

具有旋转尾巴结构或鞭毛的较大真核细胞

在某些时候吸收了这样的藻类
,形成了我们现在所说的眼虫。

Euglena 可以进行光合作用,

利用氧气分解糖分,

并在池塘水周围游泳。

正如理论所预测的那样,

这些裸藻中的叶绿体
有三层膜,

因为它们在被吞噬之前有两层。 内共生理论

的吸收过程

使生物体能够结合
强大的能力

来更好地适应地球上的生活。

结果是物种的
能力远远

超过了它们作为独立生物时的能力

,这是一种进化飞跃

,导致了我们今天在地球上观察到的微生物、植物

和动物