Is DNA the future of data storage Leo BearMcGuinness

Let’s say there’s a disaster that sends
humanity back to the Stone Age.

Can our knowledge and history survive?

The printed page will decompose.

Hard drive storage will deteriorate.

Even stones will eventually crumble.

But we might have something inside us that
can outlast these physical limitations:

deoxyribonucleic acid.

DNA already stores
our biological information.

From eye color to skin tone,
it programs our entire bodies.

DNA is made of four organic bases:

adenine,

guanine,

cytosine,

and thymine,

or A, G, C, and T.

The specific sequence of these bases
into groups of three, known as codons,

gives our cells instructions to make
each of the proteins in our bodies.

But this code can
be used for other things, too,

like secret messages.

In 1999, scientists in New York
created an alphabet

in which each of the 64
possible DNA codons

substituted for a specific letter,
number, or grammar symbol.

They spliced a 22-character message
into a long strand of DNA

and surrounded it with specific
genetic markers.

They then hid the DNA over a period
in a type-written letter

with only a small smudge
to give the location away.

They mailed the letter back to themselves.

Then they examined the letter
looking for the DNA strand.

Once the DNA strand was located,
they found the genetic markers.

Then, they sequenced the DNA
and successfully decoded the message.

It soon became obvious
that DNA cryptography

could code for much more
than simple text.

By translating the 1’s and 0’s
of binary code into DNA codons,

digital data could be programmed
into synthetic DNA,

then decoded back into its original form.

In 2012, UK scientists encoded
739 kilobytes of computer files

into DNA strands,

including all 154 Shakespeare sonnets

and an excerpt from Martin
Luther King’s “I Have a Dream” speech.

And four years later, researchers at
Microsoft and the University of Washington

broke that record.

They used binary coding to capture
a whopping 200 megabytes of data,

including the Universal Declaration
of Human Rights

and a high-def OK Go music video,

all in strings of DNA.

As far as storage capacity goes,

DNA stands out because of the surprising
amount of information it can hold

in so little space.

The current theoretical limit
of DNA’S storage capacity is so high

that you could fit 100 million HD movies
on a pencil eraser.

It’s even conceivable that one day
we could fit all of the information

currently on the Internet

into the space of a shoe box.

Also, computers and the magnetic tape and
discs that their information is stored on

only last for a few decades, at most,
before degrading and becoming unreliable.

Meanwhile, DNA
has a half-life of 500 years,

meaning that’s how long it takes
for half of its bonds to break.

And if left in a cold
and dark environment,

DNA could potentially last
for hundreds of thousands of years.

And if that isn’t long enough,

scientists experimented with having
synthetic DNA auto-reproduce.

After creating their own strands of DNA

that spelled out the lyrics to
the children’s song “It’s a Small World,”

they placed them into the genome of
a microbe nicknamed Conan the Bacterium.

Conan belongs to a species
which can survive in a vacuum,

or without water, for six years,

or come out unscathed after being
exposed to a dose of radiation

1,000 times that which would kill a human.

According to the experiment,

the bacterium was able to reproduce at
least 100 generations without data loss.

Theoretically, if the organism
had redundant copies of the information

that could be used to automatically
correct mistakes,

the information could stay
preserved even longer.

So one day, you might be able to create
a living, growing, knowledge archive

in your own backyard,

and its seeds might carry
your family’s history,

a detailed breakdown
of the world’s political upheavals,

or the sum of humanity’s knowledge
into forests and across continents.

Perhaps even into the
far reaches of space.

Though we might one day disappear,
perhaps our legacy can still live on,

if anyone would think to find it.

假设有一场灾难将
人类送回石器时代。

我们的知识和历史可以保存下来吗?

打印的页面会分解。

硬盘存储会恶化。

即使是石头最终也会崩溃。

但我们体内可能有一些东西
可以超越这些物理限制:

脱氧核糖核酸。

DNA 已经存储
了我们的生物信息。

从眼睛颜色到肤色,
它为我们的整个身体编程。

DNA 由四种有机碱基组成:

腺嘌呤、

鸟嘌呤、

胞嘧啶

和胸腺嘧啶,

或 A、G、C 和 T。

这些碱基的特定序列
分为三个一组,称为密码子,

为我们的细胞提供了制造
每种碱基的指令 我们体内的蛋白质。

但是这个代码也
可以用于其他事情,

比如秘密消息。

1999 年,纽约的科学家
创建了一个字母表

,其中 64 种
可能的 DNA 密码子中的每一种都

替换了特定的字母、
数字或语法符号。

他们将一条 22 个字符的信息拼接
成一长串 DNA

,并用特定的
遗传标记将其包围。

然后,他们将 DNA 隐藏
在一封打字信

中一段时间,只留下一小块污迹,
以泄露位置。

他们把信寄回给自己。

然后他们检查了这封信,
寻找 DNA 链。

一旦找到了 DNA 链,
他们就找到了遗传标记。

然后,他们对 DNA 进行测序
并成功解码了信息。

很快就很明显
,DNA 密码学

可以编码的
不仅仅是简单的文本。

通过将二进制代码的 1 和 0 翻译
成 DNA 密码子,

数字数据可以被编程
为合成 DNA,

然后解码回其原始形式。

2012 年,英国科学家将
739 KB 的计算机文件编码

成 DNA 链,

其中包括所有 154 首莎士比亚十四行诗


马丁路德金的“我有一个梦想”演讲的节选。

四年后,
微软和华盛顿大学的研究人员

打破了这一记录。

他们使用二进制编码来
捕获高达 200 兆字节的数据,

包括《世界人权宣言》

和高清 OK Go 音乐视频,

所有这些都包含在 DNA 字符串中。

就存储容量而言,

DNA 之所以出类拔萃,是因为
它可以

在如此小的空间内保存大量的信息。

目前
DNA 存储容量的理论极限是如此之高

,以至于你可以在铅笔橡皮擦上存储 1 亿部高清电影

甚至可以想象,有一天
我们可以将

目前互联网上的所有信息都

装进一个鞋盒的空间中。

此外,计算机以及
存储其信息的磁带和磁盘

最多只能使用几十年,
然后就会退化并变得不可靠。

同时,
DNA 的半衰期为 500 年,

这意味着它
的一半键断裂需要多长时间。

如果留在寒冷
和黑暗的环境中,

DNA 可能会
持续数十万年。

如果这还不够长,

科学家们会尝试让
合成 DNA 自动繁殖。

在创建了自己的 DNA 链

来拼出
儿歌“这是一个小世界”的歌词后,

他们将它们放入了
一种绰号为细菌柯南的微生物的基因组中。

柯南属于
一种可以在真空中

或没有水的情况下存活六年的物种,

或者在
暴露于

足以杀死人类的辐射剂量 1000 倍后毫发无损地出来。

根据实验,

该细菌能够繁殖
至少 100 代而不会丢失数据。

从理论上讲,如果有机体
拥有

可用于自动
纠正错误

的信息的冗余副本,则信息可以
保存更长时间。

所以有一天,你也许可以在你自己的后院创建
一个活生生的、不断增长的知识档案库

,它的种子可能承载着
你家族的历史、

世界政治动荡的详细分解,

或者人类知识的总和,
进入森林和跨越 大陆。

甚至可能
进入遥远的太空。

尽管有一天我们可能会消失
,但如果有人想找到它,也许我们的遗产仍然可以继续存在