Why do we itch Emma Bryce

You’re standing at
the ready inside the goal

when suddenly, you feel an intense itch
on the back of your head.

We’ve all experienced the annoyance
of an inconvenient itch,

but have you ever pondered why
we itch in the first place?

The average person experiences
dozens of individual itches each day.

They can be triggered by all sorts
of things,

including allergic reactions,

dryness,

and even some diseases.

And then there are the mysterious ones
that pop up for no reason at all,

or just from talking about itching.

You’re scratching your head right now,
aren’t you?

Anyhow, let’s take one of the most
common sources: bug bites.

When a mosquito bites you,

it releases a compound into your body
called an anticoagulant

that prevents your blood from clotting.

That compound,
which we’re mildly allergic to,

triggers the release of histamine,

a chemical that makes
our capillaries swell.

This enables increased blood flow,

which helpfully accelerates
the body’s immune response

to this perceived threat.

That explains the swelling,

and it’s the same reason pollen
can make your eyes puff up.

Histamine also activates the nerves
involved in itching,

which is why bug bites make you scratch.

But the itchy sensation itself
isn’t yet fully understood.

In fact, much of what we do know

comes from studying
the mechanics of itching in mice.

Researchers have discovered that
itch signals in their skin

are transmitted via a subclass of
the nerves that are associated with pain.

These dedicated nerves produce a molecule
called natriuretic polypetide B,

which triggers a signal that’s carried
up the spinal cord to the brain,

where it creates the feeling of an itch.

When we scratch, the action of our
fingernails on the skin

causes a low level pain signal
that overrides the itching sensation.

It’s almost like a distraction,
which creates the sensation of relief.

But is there actually an evolutionary
purpose to the itch,

or is it simply there to annoy us?

The leading theory is that our skin
has evolved to be acutely aware of touch

so that we’re equipped to deal with risks
from the outside world.

Think about it.

Our automatic scratching response
would dislodge anything harmful

that’s potentially lurking on our skin,

like a harmful sting,

a biting insect,

or the tendrils of a poisonous plant.

This might explain why we don’t
feel itching inside our bodies,

like in our intestines,

which is safe from these external threats,

though imagine how
maddening that would be.

In some people, glitches in the pathways
responsible for all of this

can cause excessive itching
that can actually harm their health.

One extreme example is a psychological
condition called delusory parasitosis

where people believe their bodies
are infested with mites or fleas

scurrying over and under their skin,

making them itch incessantly.

Another phenomenon
called phantom itching

can occur in patients
who’ve had amputations.

Because this injury has
so severely damaged the nervous system,

it confuses the body’s normal
nerve signaling

and creates sensations in limbs
that are no longer there.

Doctors are now finding ways
to treat these itching anomalies.

In amputees, mirrors are used to reflect
the remaining limb,

which the patient scratches.

That creates an illusion
that tricks the brain

into thinking the imaginary
itch has been satisfied.

Oddly enough, that actually works.

Researchers are also searching
for the genes involved in itching

and developing treatments to try
and block the pathway of an itch

in extreme cases.

If having an unscratchable itch
feels like your own personal hell,

Dante agreed.

The Italian poet wrote about
a section of hell

where people were punished by being
left in pits to itch for all eternity.

当你
在球门内准备好

时,突然,你感到后脑勺一阵剧烈的
瘙痒。

我们都经历
过不方便的痒的烦恼,

但你有没有想过我们为什么会
痒?

普通人每天会经历
数十次单独的瘙痒。

它们可以由
各种事物触发,

包括过敏反应、

干燥,

甚至某些疾病。

然后还有一些神秘的
东西,根本就没有理由突然出现,

或者只是因为谈论瘙痒。

你现在在挠头,
不是吗?

无论如何,让我们采用最
常见的来源之一:虫咬。

当蚊子叮咬您时,

它会向您的体内释放一种
称为抗凝剂

的化合物,以防止您的血液凝结。

这种我们对它有轻微过敏的化合物

会触发组胺的释放,组胺是

一种使
我们的毛细血管膨胀的化学物质。

这可以增加血流量,

这有助于
加速身体

对这种感知威胁的免疫反应。

这就解释了肿胀

,这也是花粉
会使你的眼睛浮肿的原因。

组胺还能激活与
瘙痒有关的神经,

这就是为什么虫咬会让你抓挠的原因。

但瘙痒的感觉本身
还没有被完全理解。

事实上,我们所知道的大部分知识

都来自
对老鼠瘙痒机制的研究。

研究人员发现,
他们皮肤

中的瘙痒信号
是通过与疼痛相关的神经亚类传递的。

这些专用神经产生一种
称为利钠肽 B 的分子,

该分子会触发一个信号,该信号
通过脊髓传送到大脑,

在那里它会产生瘙痒的感觉。

当我们抓挠时,我们的
指甲在皮肤上的作用

会导致一种低水平的疼痛信号
,这种信号会超越瘙痒的感觉。

这几乎就像是一种分心,
它产生了一种解脱的感觉。

但是,痒真的有进化的
目的,

还是只是为了惹恼我们?

主要理论是,我们的皮肤
已经进化到能够敏锐地感知触摸,

因此我们有能力应对
来自外部世界的风险。

想想看。

我们的自动搔抓反应
会驱走任何

可能潜伏在我们皮肤上

的有害物质,比如有害的刺痛

、叮咬的昆虫

或有毒植物的卷须。

这或许可以解释为什么我们不会像在
我们的肠道内一样感到身体内部瘙痒,

因为肠道是安全的,不受这些外部威胁的影响,

尽管想象
那会是多么令人抓狂。

在某些人中,导致所有这些问题的通路出现故障

会导致过度瘙痒
,这实际上会损害他们的健康。

一个极端的例子是一种
称为妄想性寄生虫病的心理状况

,人们认为他们的身体
被螨虫或跳蚤

在他们的皮肤上下乱窜,

使他们不断发痒。

另一种
称为幻影瘙痒的现象

可能发生在
截肢患者身上。

由于这种
损伤严重损害了神经系统,

它会混淆身体的正常
神经信号,

并在四肢
中产生不再存在的感觉。

医生现在正在寻找
治疗这些瘙痒异常的方法。

在截肢者中,镜子被用来反射

患者抓挠的剩余肢体。

这会产生一种错觉
,诱使

大脑认为想象中的
痒已经得到满足。

奇怪的是,这确实有效。

研究
人员还在寻找与瘙痒有关的基因,

并开发治疗方法,以尝试在极端情况
下阻断瘙痒的途径

。 但丁同意,

如果有一种难以捉摸的瘙痒
感觉就像你自己的地狱,

但丁同意了。

这位意大利诗人写过
一段地狱

,人们在那里受到惩罚,被
留在坑里永远发痒。