Who you are is more important than who you arent

Transcriber: Cinthia Hernandez
Reviewer: David DeRuwe

I remember feeling incredibly small,
nothing more than a distraction,

right before I got up
to present my research in Tokyo

to a group of the world’s leading
cochlear implant researchers and surgeons.

I’d been hoping for a poster presentation,

maybe even a small PowerPoint
in one of the side rooms.

What I got instead was a prime time slot
in the main symposium

in front of 500 surgeons and professors,

many of whom had been practicing
for more than 30 years.

I’m young, as far
as researchers and doctors go,

but I cared deeply
about my team’s research,

which thanks to the novel
use of hydraulics,

had the capacity to make
a real difference to people’s lives.

Sitting down, waiting my turn,

on my left was an Italian
professor of surgery

representing a multi-million dollar
research team from Europe,

complete with their very own promo guy.

Across the aisle, his main competitor
was a Japanese professor,

esteemed and valued in the community,

who was also presenting
to the world for the first time,

a similar surgical robot.

In third place was myself.

Actually, I think third place
might have been a little bit generous.

I felt like one of the kids
who plays at halftime as entertainment,

to be honest.

(Laughter)

Sitting there waiting my turn,
with about 27 years less experience

than the two professors
sitting on either side of me,

I really wished I was doing
a poster presentation.

Cochlear implantation
is an amazing technology.

It gives an artificial sense
of hearing to the deaf

through a two-centimeter bit of plastic,
a little bit skinnier than a noodle.

This techno-noodle is implanted
into your ear by a specialist ear surgeon,

and whilst the results
aren’t quite as good as normal hearing,

they’re a fair bit better than nothing.

We used to only implant
those who were totally deaf,

either those who were deafened
through rotten luck

or were born without their hearing organ,
the cochlea, functioning quite right.

But in the mid 2000s,
we started to implant more and more

those who had age-related hearing loss,

who still had a tiny bit of not-quite-
so-useless hearing function left.

Now, age-related hearing loss

is a little bit different
from other types of hearing loss.

It tends to disproportionately
affect the higher frequencies more,

which is why grandparents
can sometimes have a difficult time

hearing their grandchildren
with their squeaky voices.

It’s kind of funny, but it’s actually
a really tough thing.

If there’s one thing
that grandparents really care about,

it’s their ability to communicate,
in particular with their grandchildren.

Now, it can still be a little
bit hard for us to imagine,

so let’s pretend that half of us
develop moderate to severe hearing loss

at some point in our lives.

At that level,

you can’t have a conversation
with the person sitting next to you

without one of you having to shout
to make yourself heard.

It’s a real impediment to communication,
and it’s not that unlikely, either,

considering 50% of people
over the age of 65

are affected by moderate
to severe hearing loss.

And for us, when we hit our 60s,
those numbers will be much higher,

considering growing evidence
about the long term use of headphones.

Now, we do have hearing aids,
and they are great,

they’re used for this exact reason,
but they have their limitations.

They’re pretty difficult
for old arthritic hands,

and they’re not very effective in those
who have severe or profound hearing loss,

which is quite a lot of people.

Scientists started to realize

that if you could preserve
someone’s residual hearing

whilst complementing it with that

of the artificial sense of hearing
from a cochlear implant,

the outcomes were much better,

particularly for nuanced
sounds like music,

tone, and conversation in noisy places.

The problem was we had
no idea how to do this.

Generally, it was taken as a given

that once you put
a cochlear implant into a patient,

you destroyed that patient’s
remaining hearing,

because the tiny movements associated
with putting an implant inside the ear

are the equivalent of a jet plane
taking off right next to your head.

It’s very loud and likely to ruin
all of your remaining hearing.

Now, that’s where my team’s
research comes into play.

We’re looking at hearing preservation
in cochlear implantation,

and at this point, I have to pay tribute
to my research supervisors:

Professor Gunesh Rajan,
Professor David Fletcher,

Dr. Aanand Acharya,
and Miss Dayse Tavora-Vieira.

Without them, I simply wouldn’t
be standing here today.

We all have our own roles in the team.

My role is to work in the laboratory,

coming up with new ways of trying
to reduce the variation in pressure

inside the cochlea during surgery.

The surgery itself
is incredibly intricate and tiny.

It takes a very steady hand
and decades of practice.

It’s actually not that different
to the board game “Operation,”

but it’s just the stakes
are slightly higher.

(Laughter)

My research was difficult because we were
having problems with human variability.

Namely, any variable I investigated

was dwarfed in comparison
to the innate human tremor,

which made the use of a surgical
robot an obvious choice.

Now, we do have a photo here,
but I must warn you this is real science.

It’s scary confronting stuff.

Please don’t be blown away
by how awesome it is.

Ready. Here we go.

(Laughter)

Yes, that is masking tape.
Yes, that is Blu-Tack there.

Yes, that is a clamp
from my local hardware store.

Look, it was a simple handheld device

which produced a slow, reproducible
insertion over the course of a minute,

and it was about as simple as something
you’d expect to find in a box of Lego.

I was shocked to find out that this device
not only matched our best surgical efforts

but matched the best efforts

of the leading surgeons
from around the world,

not with an expensive contraption
but with a $15 Lego rip-off.

We actually tested this experimentally.

The very best implant surgeon in the world

could only produce an insertion
that was about half as good as our device

with respect to variation
of pressure inside the cochlea.

All of a sudden, we had a device that had
the capacity to take cochlear implantation

into the next phase for the price
of three overpriced coffees.

So we took this idea to Japan.

Now, I’ll be honest,
I felt like a total fraud.

I was presenting
on novel developing ideas,

and I was the first
of three surgical robots

to be presented to the world
for the first time that day.

Surgical robots aren’t even that common,
even at a surgical conference,

so the odds were pretty small.

In any case, I got up on the dais,
I made my presentation -

the only speaker not a professor,

the only research team not backed by
millions of dollars of research funding.

I said my bit, I answered a few
polite questions, and I sat back down,

and it wasn’t until after the presentation
that I started to realize

that we might have
something of real value here.

People were coming up to us
and asking us all sorts of questions:

“Have you commercialized the device yet?”
“Is the intellectual property for sale?”

“Have you tested this in humans?”

I was blown away that a device so simple
could be held in such high regard

by the scientific community.

Even now, we’re in conversation
with companies overseas,

looking to develop our ideas
to incorporate into widespread models.

I’d been so focused on my age,

inexperience, and the relative
simplicity of my research

that I hadn’t thought about its value
to the wider community.

Now, I’m not pretending to be the next
great researcher or surgeon out there;

I’m just trying
to be a good one right now.

But I think the real lesson in this

is that great ideas don’t have
to be complex ones,

and they don’t have to come
from someone with years of experience.

On that stage in Tokyo,
I was so focused on what I wasn’t

that I forgot about what I was.

I was young, inexperienced,

but I was coming at the problem
from a fresh angle,

and I had no idea that I had the capacity
to help millions of people.

If you’ve got a problem,
and you’re passionate about fixing it,

that’s all that matters.

Thank you.

(Applause)

抄写员:Cinthia Hernandez
审稿人:David DeRuwe

我记得

在我起身

向一群世界领先的
人工耳蜗植入研究人员和外科医生介绍我在东京的研究之前,我感到非常渺小,只不过是一种分心。

我一直希望有一个海报展示,

甚至可能是在一个侧厅里放一个小 PowerPoint

相反,我得到的是主要研讨会的黄金时段
,在

500 名外科医生和教授面前进行,

其中许多人已经
执业超过 30 年。

就研究人员和医生而言,我还很年轻,

但我非常
关心我团队的研究,

这要归功于
液压技术的新颖使用,它

能够真正改变人们的生活。

坐在我左边的是一位意大利
外科教授,他

代表着一个来自欧洲的数百万美元
研究团队

,还有他们自己的宣传员。

隔着过道,他的主要竞争对手
是一位

在社会上受人尊敬和重视的日本教授,

他还
首次向世界展示

了类似的手术机器人。

排在第三位的是我自己。

实际上,我认为第三名
可能有点慷慨。 老实说,

我觉得自己像一个
在中场休息时玩耍的孩子

(笑声)

坐在那里等轮到我,我的
经验


坐在我两边的两位教授少了大约 27 年,

我真希望我在做
一个海报展示。

人工耳蜗植入
是一项了不起的技术。

通过两厘米长的塑料给
聋哑人一种人工听觉,比面条更瘦一点。

这种技术面条
由专业的耳外科医生植入您的耳朵

,虽然
结果不如正常听力好,

但总比没有好。

我们过去只植入
那些完全耳聋的人,

要么是那些因运气不好而耳聋的人,

要么是天生就没有听力器官
,耳蜗,功能完全正常的人。

但是在 2000 年代中期,
我们开始植入越来越多

的与年龄相关的听力损失的人,

他们仍然有一点点
不那么无用的听力功能。

现在,与年龄相关的听力损失

与其他类型的听力损失有点不同。

它往往会不成比例地
影响更高的频率,

这就是为什么祖父母
有时很难

用他们吱吱作响的声音听到孙辈的声音。

这有点好笑,但实际上这是
一件非常困难的事情。

如果
祖父母真正关心一件事,

那就是他们的沟通能力
,尤其是与孙子孙女的沟通能力。

现在,我们仍然
有点难以想象,

所以让我们假设我们中有一半人在生活中的某个阶段
会出现中度至重度听力损失

在那个级别上,

你不能
与坐在你旁边的人交谈,而你们中的

一个人必须大声喊叫
才能听到自己的声音。

考虑到 50%
的 65 岁以上的

人受到中度
至重度听力损失的影响,这确实是沟通的障碍,而且也不是那么不可能。

对我们来说,当我们到了 60 多岁时

考虑到越来越多的
关于长期使用耳机的证据,这些数字会更高。

现在,我们确实有助听器
,它们很棒,

它们的使用正是出于这个原因,
但它们有其局限性。

对于患有关节炎的老手来说,它们非常困难,对于

那些有严重或极重度听力损失的人来说,它们不是很有效,

这是相当多的人。

科学家们开始意识到

,如果你可以保留
某人的残余听力,

同时用

人工耳蜗植入的人工听觉
来补充它

,结果会好得多,

尤其是对于
音乐、

音调和嘈杂环境中的谈话等细微的声音。

问题是我们
不知道如何做到这一点。

通常,人们认为一旦

将人工耳蜗植入患者体内

,就会破坏患者
剩余的听力,

因为
将植入物植入耳内的微小动作

相当于一架喷气式飞机
在旁边起飞。 你的头。

它非常响亮,可能会破坏
您所有剩余的听力。

现在,这就是我团队的
研究发挥作用的地方。

我们正在研究人工耳蜗植入中的听力保护

,在这一点上,我必须
向我的研究导师致敬:

Gunesh Rajan
教授、David Fletcher 教授、

Aanand Acharya 博士
和 Dayse Tavora-Vieira 小姐。

没有他们,我
今天根本不会站在这里。

我们在团队中都有自己的角色。

我的职责是在实验室工作,

想出新的方法
来减少

手术过程中耳蜗内的压力变化。

手术本身
非常复杂和微小。

这需要非常稳定的手
和数十年的实践。

它实际上
与棋盘游戏“行动”

没有什么不同,只是
赌注略高。

(笑声)

我的研究很困难,因为我们
遇到了人类变异性的问题。

也就是说,与先天的人类震颤相比,我研究的任何变量

都相形见绌

这使得使用手术
机器人成为一个明显的选择。

现在,我们确实有一张照片,
但我必须警告你这是真正的科学。

面对事情很可怕。

请不要
被它的真棒所震撼。

准备好。 开始了。

(笑声)

是的,那是胶带。
是的,那里就是 Blu-Tack。

是的,那
是我当地五金店的夹子。

看,这是一个简单的手持设备,它在一分钟内

产生了一个缓慢的、可重复的
插入

,它和
你期望在乐高盒子里找到的东西一样简单。

我震惊地发现,这款设备
不仅与我们最好的外科手术

相匹配,而且与来自世界各地的领先外科医生的最大努力相匹配

不是昂贵的装置,
而是 15 美元的乐高玩具。

我们实际上对此进行了实验测试。

就耳蜗内压力的变化而言,世界上最好的植入外科医生

只能生产
出大约是我们设备一半的植入物

突然间,我们有了一个
能够以三杯高价咖啡的价格将人工耳蜗

植入下一阶段的设备

所以我们把这个想法带到了日本。

现在,老实说,
我觉得自己像个彻头彻尾的骗子。

我正在
展示新颖的发展理念

,我是当天首次向世界展示
的三个手术机器人

中的第一个。

即使在外科会议上,手术机器人也并不常见,

所以可能性很小。

无论如何,我在讲台上站了起来,
我做了我的演讲

——唯一的演讲者不是教授

,唯一的研究团队没有
数百万美元的研究资金支持。

我说了我的一点,我回答了几个
礼貌的问题,然后我坐了下来

,直到演讲结束后
,我才开始

意识到我们
在这里可能有一些真正有价值的东西。

人们向我们
走来问我们各种各样的问题:

“你已经将设备商业化了吗?”
“知识产权出售吗?”

“你在人类身上测试过这个吗?”

如此简单的设备

受到科学界的高度重视,我感到非常震惊。

即使是现在,我们仍在
与海外公司进行对话,

希望将我们的
想法融入到广泛的模型中。

我一直专注于我的年龄、

缺乏经验和
我的研究相对简单,

以至于我没有想到它对
更广泛的社区的价值。

现在,我不会假装成为下一个
伟大的研究员或外科医生。

我现在只是
想成为一个好人。

但我认为真正的教训

是伟大的想法
不一定是复杂的

,也不一定
来自有多年经验的人。

在东京的那个舞台上,
我如此专注于我不是什么

,以至于我忘记了我是什么。

我很年轻,没有经验,

但我
从一个全新的角度来解决这个问题

,我不知道我有
能力帮助数百万人。

如果您遇到问题,
并且热衷于解决问题,

那才是最重要的。

谢谢你。

(掌声)