Why is meningitis so dangerous Melvin Sanicas

In 1987, tens of thousands of people

gathered in Saudi Arabia
for the annual Hajj pilgrimage.

But what started out as a celebration
led to a health crisis:

just a few days after the pilgrimage,

more than 2,000 cases
of meningitis broke out

spreading across Saudi Arabia
and the rest of the world.

The outbreak was so fierce

that it was believed to have sparked a
wave of deadly meningitis epidemics

that ultimately infected tens of
thousands of people worldwide.

Meningitis is the inflammation
of the meninges,

three tissue layers responsible for
protecting the brain and spinal cord.

What makes meningitis so dangerous
compared to other diseases

is the sheer speed with which
it invades a person’s body.

In the worst cases, it causes death
within a day.

Fortunately, that’s rare for patients
who receive early medical treatment.

The disease primarily
comes in three forms:

fungal, viral, and bacterial–
the last being the most deadly by far,

and what we’ll focus on.

People usually contract bacterial
meningitis by breathing in

tiny particles of mucus and
saliva that spray into the air

when an infected person
sneezes or coughs.

It can also be transmitted
through kissing,

or sharing cigarettes,
toothbrushes or utensils.

Some people can be infected
and carry the disease

without showing symptoms
or getting sick,

which helps the disease
spread quickly to others.

Once the bacteria enter
the nose, mouth, and throat,

they cross the surrounding
membranes and enter the bloodstream.

From there, bacteria have
rapid access to the body’s tissues

–including a membrane
called the blood-brain barrier.

This is made of a tight mesh of cells which
separate blood vessels from the brain,

and block everything except
for a specific set of particles,

including water molecules and some gases.

But in ways that scientists are
still trying to understand,

meningitis bacteria can trick
the barrier into letting them through.

Inside the brain, the bacteria swiftly
infect the meninges.

This triggers inflammation as the body’s
immune response kicks into overdrive,

bringing on fever
and intense headaches.

As swelling in the meninges worsens,
the neck begins to stiffen.

Swelling in the brain disrupts its
normal function–

causing symptoms like hearing loss
and extreme light sensitivity.

As pressure increases in the cranium,
it may also make the person confused–

one of the hallmarks
of the disease.

A few hours in, the rapidly multiplying
bacteria start to release toxins,

leading to septicemia,
also known as blood poisoning.

This breaks down blood vessels,

letting blood seep out and form what
starts out looking like a rash,

and evolves into big discoloured blots
beneath the skin.

At the same time, these toxins
burn through oxygen in the blood,

reducing the amount that gets to
major organs like the lungs and kidneys.

That increases the chance
of organ shut down

–and alongside spreading
septicemia, threatens death.

That all sounds scary, but doctors are so
good at treating meningitis

that a visit to the hospital can drastically
reduce an adult’s risk of dying from it.

The longer it’s left
untreated, though,

the more likely it will lead
to lasting damage.

If declining oxygen levels cause cell
death in extreme parts of the body

–like fingers, toes, arms and legs–
the risk of amputation goes up.

And if bacterial toxins accumulate
in the brain and trigger cell death,

meningitis could also cause long-term
brain damage and memory loss.

So fast treatment, or better yet,
prevention, is critical.

That’s why most countries have
vaccines that defend against the disease

in its deadliest forms.

Those are usually given to the people who
are most at risk–like young children,

people with weak immune systems,
or people who gather in large groups

where an outbreak of meningitis
could potentially happen.

In addition to those gatherings,

meningitis is most common in
a region called the meningitis belt

that stretches across Africa, though cases
do happen all over the world.

If you’re concerned that you or someone
you know may have meningitis,

get to the doctor as soon as possible;

quick action could save your life.

1987年,数万人

齐聚沙特阿拉伯
,参加一年一度的朝觐。

但最初的庆祝活动
导致了一场健康危机:

朝圣后仅几天,

沙特阿拉伯
和世界其他地区爆发了 2000 多例脑膜炎病例。

爆发如此猛烈

,以至于人们认为它引发了
一波致命的脑膜炎流行病

,最终感染
了全世界成千上万的人。

脑膜炎是脑膜的炎症
,脑膜是

负责
保护大脑和脊髓的三个组织层。

与其他疾病相比,脑膜炎如此危险的原因

在于
它侵入人体的绝对速度。

在最坏的情况下,它会
在一天内导致死亡。

幸运的是,这对于
接受早期治疗的患者来说很少见。

这种疾病
主要以三种形式出现:

真菌、病毒和细菌——
最后一种是迄今为止最致命的,

也是我们将关注的重点。

人们通常
通过吸入

微小的粘液和
唾液颗粒来感染细菌性脑膜炎,当感染者打喷嚏或咳嗽时,这些颗粒会喷到空气中

它也可以
通过接吻

或共用香烟、
牙刷或餐具传播。

有些人可以在

没有出现症状
或生病的情况下被感染并携带疾病,

这有助于疾病
迅速传播给其他人。

一旦细菌
进入鼻子、嘴巴和喉咙,

它们就会穿过周围的
膜进入血液。

从那里,细菌可以
迅速进入人体组织——包括

一种叫做血脑屏障的膜

这是由紧密的细胞网组成的,这些细胞
将血管与大脑分开,

并阻挡
除了一组特定的粒子(

包括水分子和一些气体)之外的一切。

但以科学家
仍在试图理解的方式,

脑膜炎细菌可以
欺骗屏障让它们通过。

在大脑内部,细菌迅速
感染脑膜。

当身体的
免疫反应超速运转时,这会

引发炎症,导致发烧
和剧烈头痛。

随着脑膜肿胀恶化
,颈部开始变硬。

大脑肿胀会破坏其
正常功能——

导致听力丧失
和极度光敏感等症状。

随着颅内压力的增加,
它也可能使人感到困惑

——这
是该疾病的标志之一。

几个小时后,快速繁殖的
细菌开始释放毒素,

导致败血症,
也称为血液中毒。

这会破坏血管,

让血液渗出并形成一
开始看起来像皮疹的东西,

并在皮肤下演变成大的变色斑点

同时,这些毒素会
燃烧血液中的氧气,

从而减少进入
肺和肾脏等主要器官的量。

这增加了器官关闭的机会

——并且随着
败血症的传播,威胁着死亡。

这一切听起来很可怕,但医生非常
擅长治疗脑膜炎

,因此去医院就诊可以大大
降低成年人死于脑膜炎的风险。 然而,未经治疗

的时间越长

,它就越有可能
导致持久的损害。

如果氧气水平下降导致
身体极端部位(如

手指、脚趾、手臂和腿)
的细胞死亡,截肢的风险就会增加。

如果细菌毒素
在大脑中积聚并引发细胞死亡,

脑膜炎也可能导致长期
脑损伤和记忆丧失。

因此,快速治疗,或者更好的
预防,是至关重要的。

这就是为什么大多数国家都有
疫苗可以抵御

最致命的疾病。

这些通常提供给
风险最高的人,例如幼儿、

免疫系统较弱的人
或可能会爆发脑膜炎的大群体聚集的人

除了这些聚会之外,

脑膜炎在横跨非洲的
一个叫做脑膜炎带的地区最为常见

,尽管
世界各地确实发生了病例。

如果您担心自己或
您认识的人可能患有脑膜炎,请

尽快就医;

快速行动可以挽救你的生命。