Latif Nasser The amazing story of the man who gave us modern pain relief

A few years ago,

my mom developed rheumatoid arthritis.

Her wrists, knees and toes swelled up,
causing crippling, chronic pain.

She had to file for disability.

She stopped attending our local mosque.

Some mornings it was too painful
for her to brush her teeth.

I wanted to help.

But I didn’t know how.

I’m not a doctor.

So, what I am is a historian of medicine.

So I started to research
the history of chronic pain.

Turns out, UCLA has an entire
history of pain collection

in their archives.

And I found a story –
a fantastic story –

of a man who saved – rescued –
millions of people from pain;

people like my mom.

Yet, I had never heard of him.

There were no biographies
of him, no Hollywood movies.

His name was John J. Bonica.

But when our story begins,

he was better known as
Johnny “Bull” Walker.

It was a summer day in 1941.

The circus had just arrived
in the tiny town of Brookfield, New York.

Spectators flocked to see
the wire-walkers, the tramp clowns –

if they were lucky, the human cannonball.

They also came to see the strongman,
Johnny “Bull” Walker,

a brawny bully who’d pin you for a dollar.

You know, on that particular day,
a voice rang out

over the circus P.A. system.

They needed a doctor urgently,
in the live animal tent.

Something had gone wrong
with the lion tamer.

The climax of his act had gone wrong,

and his head was stuck
inside the lion’s mouth.

He was running out of air;

the crowd watched in horror

as he struggled and then passed out.

When the lion finally did relax its jaws,

the lion tamer just slumped
to the ground, motionless.

When he came to a few minutes later,

he saw a familiar figure hunched over him.

It was Bull Walker.

The strongman had given the lion tamer
mouth-to-mouth, and saved his life.

Now, the strongman hadn’t told anyone,

but he was actually
a third-year medical student.

He toured with the circus
during summers to pay tuition,

but kept it a secret
to protect his persona.

He was supposed to be
a brute, a villain –

not a nerdy do-gooder.

His medical colleagues didn’t
know his secret, either.

As he put it, “If you were
an athlete, you were a dumb dodo.”

So he didn’t tell them about the circus,

or about how he wrestled professionally
on evenings and weekends.

He used a pseudonym like Bull Walker,

or later, the Masked Marvel.

He even kept it a secret that same year,

when he was crowned
the Light Heavyweight Champion

of the world.

Over the years, John J. Bonica
lived these parallel lives.

He was a wrestler;

he was a doctor.

He was a heel;

he was a hero.

He inflicted pain,

and he treated it.

And he didn’t know it at the time,
but over the next five decades,

he’d draw on these dueling identities

to forge a whole new way
to think about pain.

It’d change modern medicine
so much so, that decades later,

Time magazine would call him
pain relief’s founding father.

But that all happened later.

In 1942, Bonica graduated
medical school and married Emma,

his sweetheart, whom he had met
at one of his matches years before.

He still wrestled in secret – he had to.

His internship at New York’s
St. Vincent’s Hospital paid nothing.

With his championship belt,
he wrestled in big-ticket venues,

like Madison Square Garden,

against big-time opponents,

like Everett “The Blonde Bear” Marshall,

or three-time world champion,
Angelo Savoldi.

The matches took a toll on his body;

he tore hip joints, fractured ribs.

One night, The Terrible Turk’s big toe
scratched a scar like Capone’s

down the side of his face.

The next morning at work,
he had to wear a surgical mask to hide it.

Twice Bonica showed up to the O.R.
with one eye so bruised,

he couldn’t see out of it.

But worst of all were
his mangled cauliflower ears.

He said they felt like two baseballs
on the sides of his head.

Pain just kept accumulating in his life.

Next, he watched his wife go
into labor at his hospital.

She heaved and pushed, clearly in anguish.

Her obstetrician called
out to the intern on duty

to give her a few drops of ether
to ease her pain.

But the intern was a young guy,
just three weeks on the job –

he was jittery, and in applying the ether,

irritated Emma’s throat.

She vomited and choked,
and started to turn blue.

Bonica, who was watching all this,
pushed the intern out of the way,

cleared her airway,

and saved his wife
and his unborn daughter.

At that moment, he decided
to devote his life to anesthesiology.

Later, he’d even go on to help develop
the epidural, for delivering mothers.

But before he could focus on obstetrics,

Bonica had to report for basic training.

Right around D-Day,

Bonica showed up
to Madigan Army Medical Center,

near Tacoma.

At 7,700 beds, it was one of the largest
army hospitals in America.

Bonica was in charge
of all pain control there.

He was only 27.

Treating so many patients,
Bonica started noticing cases

that contradicted everything
he had learned.

Pain was supposed to be
a kind of alarm bell – in a good way –

a body’s way of signaling an injury,
like a broken arm.

But in some cases,

like after a patient had a leg amputated,

that patient might still complain
of pain in that nonexistent leg.

But if the injury had been treated, why
would the alarm bell keep ringing?

There were other cases in which there
was no evidence of an injury whatsoever,

and yet, still the patient hurt.

Bonica tracked down all the specialists
at his hospital – surgeons,

neurologists, psychiatrists, others.

And he tried to get
their opinions on his patients.

It took too long, so he started organizing
group meetings over lunch.

It would be like a tag team of specialists
going up against the patient’s pain.

No one had ever focused on pain
this way before.

After that, he hit the books.

He read every medical textbook
he could get his hands on,

carefully noting every mention
of the word “pain.”

Out of the 14,000 pages he read,

the word “pain” was
on 17 and a half of them.

Seventeen and a half.

For the most basic, most common,
most frustrating part of being a patient.

Bonica was shocked – I’m quoting him,

he said, “What the hell kind of conclusion
can you come to there?

The most important thing
from the patient’s perspective,

they don’t talk about.”

So over the next eight years,
Bonica would talk about it.

He’d write about it; he’d write
those missing pages.

He wrote what would later be known
as the Bible of Pain.

In it he proposed new strategies,

new treatments using
nerve-block injections.

He proposed a new institution,
the Pain Clinic,

based on those lunchtime meetings.

But the most important thing
about his book

was that it was kind of an emotional
alarm bell for medicine.

A desperate plea to doctors
to take pain seriously

in patients' lives.

He recast the very purpose of medicine.

The goal wasn’t to make patients better;

it was to make patients feel better.

He pushed his pain agenda for decades,

before it finally took hold
in the mid-’70s.

Hundreds of pain clinics sprung up
all over the world.

But as they did – a tragic twist.

Bonica’s years of wrestling
caught up to him.

He had been out of the ring
for over 20 years,

but those 1,500 professional bouts
had left a mark on his body.

Still in his mid-50s, he suffered
severe osteoarthritis.

Over the next 20 years
he’d have 22 surgeries,

including four spine operations,

and hip replacement after hip replacement.

He could barely raise
his arm, turn his neck.

He needed aluminum crutches to walk.

His friends and former students
became his doctors.

One recalled that he probably
had more nerve-block injections

than anyone else on the planet.

Already a workaholic,
he worked even more –

15- to 18-hour days.

Healing others became more
than just his job,

it was his own most effective
form of relief.

“If I wasn’t as busy as I am,”
he told a reporter at the time,

“I would be a completely disabled guy.”

On a business trip to Florida
in the early 1980s,

Bonica got a former student to drive
him to the Hyde Park area in Tampa.

They drove past palm trees
and pulled up to an old mansion,

with giant silver howitzer cannons
hidden in the garage.

The house belonged to the Zacchini family,

who were something like
American circus royalty.

Decades earlier, Bonica had watched them,

clad in silver jumpsuits and goggles,

doing the act they pioneered –
the Human Cannonball.

But now they were like him: retired.

That generation is all dead
now, including Bonica,

so there’s no way to know exactly
what they said that day.

But still, I love imagining it.

The strongman and the human
cannonballs reunited,

showing off old scars, and new ones.

Maybe Bonica gave them medical advice.

Maybe he told them what he later
said in an oral history,

which is that his time in the circus
and wrestling deeply molded his life.

Bonica saw pain close up.

He felt it. He lived it.

And it made it impossible
for him to ignore in others.

Out of that empathy, he spun
a whole new field,

played a major role in getting
medicine to acknowledge pain

in and of itself.

In that same oral history,

Bonica claimed that pain

is the most complex human experience.

That it involves your past life,
your current life,

your interactions, your family.

That was definitely true for Bonica.

But it was also true for my mom.

It’s easy for doctors to see my mom

as a kind of professional patient,

a woman who just spends her days
in waiting rooms.

Sometimes I get stuck seeing her
that same way.

But as I saw Bonica’s pain –

a testament to his fully lived life –

I started to remember all the things
that my mom’s pain holds.

Before they got swollen and arthritic,

my mom’s fingers clacked away

in the hospital H.R. department
where she worked.

They folded samosas for our entire mosque.

When I was a kid, they cut my hair,

wiped my nose,

tied my shoes.

Thank you.

(Applause)

几年前,

我妈妈患上了类风湿性关节炎。

她的手腕、膝盖和脚趾肿胀,
导致严重的慢性疼痛。

她不得不申请残疾。

她不再参加我们当地的清真寺。

有些早晨,她刷牙太疼
了。

我想帮忙。

但我不知道怎么做。

我不是医生。

所以,我是一名医学史学家。

于是我开始研究
慢性疼痛的历史。

事实证明,加州大学洛杉矶分校的档案中有完整
的疼痛收集历史

我发现了一个故事——
一个奇妙的故事

——一个人拯救了——拯救了——
数以百万计的人脱离了痛苦;

像我妈妈这样的人。

然而,我从未听说过他。

没有
他的传记,没有好莱坞电影。

他的名字是约翰·J·博尼卡。

但是当我们的故事开始时,

他被称为
约翰尼“公牛”沃克。

那是 1941 年的一个夏日。

马戏团刚刚抵达
纽约布鲁克菲尔德小镇。

观众蜂拥而至,
看走钢丝的人、流浪汉——

如果幸运的话,还有人类的炮弹。

他们还来看了强人
约翰尼·“公牛”·沃克,

一个粗壮的恶霸,只要一美元就能把你钉死。

你知道,在那一天,

马戏团 P.A. 上响起了一个声音。 系统。

他们急需一位医生,
在活体动物的帐篷里。

驯狮师出了点问题。

他的行为高潮出现了错误

,他的头被卡
在了狮子的嘴里。

他快没气了。

人群惊恐地看着

他挣扎然后昏倒。

当狮子终于放松了下巴时

,驯狮师只是
瘫倒在地,一动不动。

几分钟后

他回过神来,就看到一个熟悉的身影弯着腰。

是公牛沃克。

强人与驯狮师
口交,救了他的命。

现在,强者没有告诉任何人,

但他实际上是
一名三年级的医学生。

他在夏天与马戏团一起巡回演出
以支付学费,


为了保护自己的形象而保密。

他应该是
个畜生,一个恶棍——

而不是一个书呆子的行善者。

他的医学同事也不
知道他的秘密。

正如他所说,“如果你是
一名运动员,你就是一只愚蠢的渡渡鸟。”

所以他没有告诉他们马戏团的事,也没有告诉他们他是

如何
在晚上和周末进行职业摔跤的。

他使用了一个化名,比如 Bull Walker,

或者后来的 Masked Marvel。

同年,

当他被加冕
为世界轻重量级冠军时,他甚至保密

多年来,约翰·J·博尼卡
过着这些平行的生活。

他是一名摔跤手;

他是一名医生。

他是个脚后跟;

他是个英雄。

他造成了痛苦

,他治疗了它。

当时他并不知道,
但在接下来的五年里,

他会利用这些对决的身份

来打造一种全新的方式
来思考痛苦。

它极大地改变了现代医学
,以至于几十年后,

时代杂志称他为
止痛药的开国元勋。

但这一切都发生在后来。

1942 年,博尼卡从
医学院毕业并嫁给

了他的心上人艾玛,
这是他多年前在一场比赛中认识的。

他仍然在秘密地搏斗——他不得不这样做。

他在纽约
圣文森特医院的实习一无所获。

凭借他的冠军腰带,
他在

麦迪逊广场花园等大型场地

与大牌对手(

如“金发熊”埃弗雷特

或三届世界冠军
安吉洛萨沃尔迪等大牌对手搏斗。

火柴对他的身体造成了伤害。

他撕裂了髋关节,肋骨骨折。

一天晚上,可怕的土耳其人的大脚趾在他
的脸上划了一道像卡彭一样的伤疤

第二天早上上班,
他不得不戴上外科口罩来掩饰。

两次 Bonica 出现在手术室。
一只眼睛受了重伤,

他什么也看不见。

但最糟糕的是
他的花椰菜耳朵。

他说他们感觉就像两个棒球
在他的头上。

痛苦只是在他的生活中不断累积。

接下来,他看着他的妻子
在他的医院分娩。

她举起手推,显然是在痛苦中。

她的产科医生
叫值班实习生

给她几滴乙醚
来缓解她的疼痛。

但实习生是个年轻人,
才刚上岗三周——

他很紧张,在使用乙醚时,

艾玛的喉咙很不舒服。

她呕吐并窒息,
并开始变蓝。

看着这一切的博尼卡
将实习生推开,

清理了她的呼吸道,

并救了他的
妻子和未出生的女儿。

那一刻,他决定
将自己的一生奉献给麻醉学。

后来,他甚至继续帮助开发
用于分娩的硬膜外麻醉。

但在他能够专注于产科之前,

Bonica 不得不报到接受基础培训。

就在诺曼底登陆日前后,

博尼卡出现在塔科马附近
的马迪根陆军医疗中心

它拥有 7,700 张床位,是美国最大的
陆军医院之一。

Bonica 负责
那里的所有疼痛控制。

他只有 27 岁。

治疗了这么多病人,
Bonica 开始注意到


他所学到的一切相矛盾的病例。

疼痛应该是
一种警钟——以一种好的方式——

一种身体发出受伤信号的方式,
就像断了的胳膊一样。

但在某些情况下,

比如患者截肢后

,患者可能仍会抱怨
那条不存在的腿疼痛。

但如果伤势得到治疗,
为什么警钟会一直响起?

在其他情况下
,没有任何受伤的证据

,但患者仍然受伤。

博尼卡找到
了他所在医院的所有专家——外科医生、

神经科医生、精神科医生等等。

他试图听取
他们对他的病人的意见。

时间太长了,所以他开始
在午餐时间组织小组会议。

这就像一个由专家组成的标签团队
对抗患者的痛苦。

以前没有人以
这种方式关注疼痛。

在那之后,他打了书。

他阅读了
他能拿到的每一本医学教科书,

仔细地注意到每一次
提到“疼痛”这个词。

在他阅读的 14,000 页中

,“疼痛”一词出现
在其中的 17 页半。

十七岁半。

作为患者最基本、最常见、
最令人沮丧的部分。

博尼卡很震惊——我引用他的话,

他说,“你能得出什么样的结论

从病人的角度来看,最重要的事情,

他们不谈论。”

所以在接下来的八年里,
Bonica 会谈论它。

他会写下它; 他会写
那些缺失的页面。

他写了后来被
称为痛苦的圣经。

在其中,他提出了新的策略,

使用
神经阻滞注射的新疗法。

他根据那些午餐时间的会议提出了一个新的机构
,疼痛诊所

但他的书最重要的一点

是,它
为医学敲响了警钟。

绝望地恳求医生
认真

对待患者生活中的痛苦。

他重新塑造了医学的真正目的。

目标不是让患者变得更好;而是让患者变得更好。

这是为了让病人感觉更好。

几十年来,他一直在推动他的疼痛议程,

直到
70 年代中期才终于站稳脚跟。 世界各地

涌现出数百家疼痛诊所

但正如他们所做的那样——一个悲剧性的转折。

博尼卡多年的摔跤
追上了他。

他已经退出
擂台20多年,

但那1500场职业比赛
却在他身上留下了印记。

50多岁时,他患有
严重的骨关节炎。

在接下来的 20 年里,
他进行了 22 次手术,

包括 4 次脊柱手术,

以及一次又一次的髋关节置换手术。

他几乎无法
抬起手臂,转动脖子。

他需要铝拐杖才能走路。

他的朋友和以前的学生
成了他的医生。

有人回忆说,他可能

比地球上其他任何人都接受过更多的神经阻滞注射。 他

已经是一个工作狂,
每天工作

15 到 18 个小时。

治愈他人
不仅仅是他的工作,

而是他自己最
有效的解脱方式。

“如果我不那么忙,”
他当时告诉记者,

“我会是一个完全残疾的人。”

在 1980 年代初去佛罗里达出差时

Bonica 让一位以前的学生开车送
他到坦帕的海德公园地区。

他们驶过棕榈树
,停在一座古老的豪宅前,车库里

藏着巨大的银色榴弹炮

这所房子属于 Zacchini 家族,

他们有点像
美国马戏团的皇室成员。

几十年前,Bonica 看着他们

穿着银色连身衣和护目镜,

做着他们开创的行为
——人类炮弹。

但现在他们就像他一样:退休了。

那一代人现在都死
了,包括Bonica,

所以没有办法确切
知道他们那天说了什么。

但是,我仍然喜欢想象它。

强人与人
炮重逢,

旧伤痕与新伤痕相映生辉。

也许博尼卡给了他们医疗建议。

也许他告诉他们他后来
在口述历史中所说的话,

那就是他在马戏团和摔跤中的时光
深深地塑造了他的生活。

Bonica 近距离看到了疼痛。

他感觉到了。 他活了下来。


让他不可能忽视别人。

出于这种同理心,他
开辟了一个全新的领域,

在让药物承认疼痛本身方面发挥了重要作用

在同一口述历史中,

博尼卡声称疼痛

是人类最复杂的体验。

它涉及你的前世,
你现在的生活,

你的互动,你的家庭。

这对 Bonica 来说绝对是正确的。

但对我妈妈来说也是如此。

医生很容易把我妈妈

看成一个专业的病人,

一个整天待在候诊室的女人

有时我会
以同样的方式看到她。

但当我看到 Bonica 的痛苦——

这是他充实生活的证明——

我开始记起
我妈妈痛苦的所有事情。

在他们肿胀和关节炎之前,

我妈妈的手指在她工作的医院人力资源部发出咔哒声

他们为我们的整个清真寺折叠了咖喱角。

当我还是个孩子的时候,他们给我剪头发、

擦鼻子、

系鞋带。

谢谢你。

(掌声)