When is a pandemic over

Consider this unfortunately
familiar scenario.

Several months ago a highly infectious,
sometimes deadly respiratory virus

infected humans for the first time.

It then proliferated faster
than public health measures

could contain it.

Now the World Health Organization (WHO)
has declared a pandemic,

meaning that it’s spreading worldwide.

The death toll is starting to rise
and everyone is asking the same question:

when will the pandemic end?

The WHO will likely declare
the pandemic over

once the infection is mostly contained

and rates of transmission drop
significantly throughout the world.

But exactly when that happens depends on
what global governments choose to do next.

They have three main options:

Race through it, Delay and Vaccinate,
or Coordinate and Crush.

One is widely considered best,
and it may not be the one you think.

In the first, governments and communities
do nothing to halt the spread

and instead allow people to be exposed
as quickly as possible.

Without time to study the virus,

doctors know little about
how to save their patients,

and hospitals reach peak capacity
almost immediately.

Somewhere in the range of millions
to hundreds of millions of people die,

either from the virus
or the collapse of health care systems.

Soon the majority of people
have been infected

and either perished or survived
by building up their immune responses.

Around this point herd immunity kicks in,

where the virus can no longer
find new hosts.

So the pandemic fizzles out
a short time after it began.

But there’s another way to create
herd immunity

without such a high cost of life.

Let’s reset the clock to the moment
the WHO declared the pandemic.

This time, governments and communities
around the world

slow the spread of the virus
to give research facilities time

to produce a vaccine.

They buy this crucial time through tactics
that may include widespread testing

to identify carriers,

quarantining the infected
and people they’ve interacted with,

and physical distancing.

Even with these measures in place,
the virus slowly spreads,

causing up to hundreds of thousands
of deaths.

Some cities get the outbreak under control
and go back to business as usual,

only to have a resurgence

and return to physical distancing
when a new case passes through.

Within the next several years,

one or possibly several vaccines become
widely, and hopefully freely, available

thanks to a worldwide effort.

Once 40-90% of the population
has received it—

the precise amount varying
based on the virus—

herd immunity kicks in,
and the pandemic fizzles out.

Let’s rewind the clock one more time,
to consider the final strategy:

Coordinate and Crush.

The idea here is to simultaneously starve
the virus, everywhere,

through a combination of quarantine,
social distancing, and restricting travel.

The critical factor
is to synchronize responses.

In a typical pandemic,
when one country is peaking,

another may be getting its first cases.

Instead of every leader responding
to what’s happening in their jurisdiction,

here everyone must treat the world
as the giant interconnected system it is.

If coordinated properly, this could end
a pandemic in just a few months,

with low loss of life.

But unless the virus is completely
eradicated— which is highly unlikely—

there will be risks of it escalating
to pandemic levels once again.

And factors like animals carrying
and transmitting the virus

might undermine
our best efforts altogether.

So which strategy is best for this deadly,
infectious respiratory virus?

Racing through it is a quick fix,
but would be a global catastrophe,

and may not work at all
if people can be reinfected.

Crushing the virus through Coordination
alone is also enticing for its speed,

but only reliable with true
and nearly impossible global cooperation.

That’s why vaccination, assisted by
as much global coordination as possible,

is generally considered to be the winner;

it’s the slow, steady,
and proven option in the race.

Even if the pandemic officially ends
before a vaccine is ready,

the virus may reappear seasonally, so
vaccines will continue to protect people.

And although it may take years to create,

disruptions to most people’s lives
won’t necessarily last the full duration.

Breakthroughs in treatment
and prevention of symptoms

can make viruses much less dangerous,

and therefore require less extreme
containment measures.

Take heart: the pandemic will end.

Its legacy will be long-lasting,
but not all bad;

the breakthroughs, social services,
and systems we develop

can be used to the betterment of everyone.

And if we take inspiration
from the successes

and lessons from the failures,

we can keep the next potential
pandemic so contained

that our children’s children
won’t even know its name.

考虑一下这个不幸
熟悉的场景。

几个月前,一种高度传染性、
有时甚至是致命的呼吸道病毒

首次感染了人类。

然后它的扩散速度
超过了公共卫生措施

所能控制的速度。

现在,世界卫生组织 (WHO)
已宣布大流行,

这意味着它正在全球蔓延。

死亡人数开始上升
,每个人都在问同一个问题:

大流行什么时候结束?

一旦感染基本得到控制

并且全球传播率
显着下降,世卫组织可能会宣布大流行结束。

但究竟何时发生这种情况取决于
全球政府下一步选择做什么。

他们有三个主要选择:

通过它,延迟和疫苗接种,
或协调和粉碎。

一种被广泛认为是最好的
,它可能不是您认为的那种。

首先,政府和社区
没有采取任何措施来阻止传播

,而是让人们尽快接触到病毒

如果没有时间研究这种病毒,

医生对
如何拯救病人知之甚少

,医院几乎立即达到峰值容量

数百万
到数亿人死于病毒

或医疗保健系统的崩溃。

很快,大多数人
都被感染了

,或者通过建立免疫反应而死亡或幸存下来

大约在这一点上,群体免疫开始发挥作用

,病毒无法再
找到新的宿主。

因此,大流行
在开始后不久就消失了。

但是还有另一种方法可以在

没有如此高昂的生命成本的情况下创造群体免疫。

让我们把时钟调到
世界卫生组织宣布大流行的那一刻。

这一次,世界各地的政府和社区

减缓了病毒的传播,
让研究机构有

时间生产疫苗。

他们通过策略来争取这个关键时间,这些策略
可能包括广泛测试

以识别携带者、

隔离感染者
和他们接触过的人,

以及保持身体距离。

即使采取了这些措施
,病毒仍会缓慢传播,

导致多达数十
万人死亡。

一些城市控制住了疫情
并恢复了正常营业,

只是在出现新病例时再次出现

并恢复物理距离

在接下来的几年中,由于全球范围内的努力,

一种或可能几种疫苗会被
广泛使用,并有望免费获得

一旦 40% 至 90% 的
人口接受了疫苗(

具体数量
因病毒而异),

群体免疫就会启动
,大流行就会消失。

让我们再把时间倒回去
,考虑一下最终的策略:

协调和粉碎。

这里的想法是

通过隔离、
社会疏远和限制旅行的结合,在任何地方同时使病毒饿死。

关键因素
是同步响应。

在典型的大流行中,
当一个国家达到顶峰时,

另一个国家可能会出现第一批病例。

这里,每个人都必须将世界
视为一个巨大的互联系统,而不是每个领导者都对其管辖范围内发生的事情做出反应。

如果协调得当,这可能会
在短短几个月内结束一场大流行,

而且生命损失很小。

但是,除非病毒被完全
根除——这是极不可能的——

否则它将有
再次升级到大流行水平的风险。

动物携带和传播病毒等因素

可能会
完全破坏我们的最大努力。

那么哪种策略最适合这种致命的
传染性呼吸道病毒呢?

快速通过它是一个快速的解决方案,
但将是一场全球性的灾难,如果人们可以再次感染

,可能根本不起作用
。 仅

通过协调来消灭病毒
的速度也很诱人,

但只有在真正
且几乎不可能的全球合作下才能可靠。

这就是为什么在
尽可能多的全球协调的协助下,疫苗接种

通常被认为是赢家。

这是比赛中缓慢、稳定
且经过验证的选择。

即使大流行
在疫苗准备好之前正式结束

,病毒也可能会季节性地重新出现,因此
疫苗将继续保护人们。

尽管可能需要数年时间才能创造出来,但

对大多数人生活的破坏
不一定会持续整个过程。

在治疗
和预防症状方面的突破

可以使病毒的危险性大大降低

,因此需要较少的极端
遏制措施。

振作起来:大流行将结束。

它的遗产将是持久的,
但并非都是坏事; 我们开发

的突破、社会服务
和系统

可用于改善每个人。

如果我们
从成功

中汲取灵感并从失败中汲取教训,

我们就可以控制下一次潜在的
流行病,

以至于我们孩子的
孩子甚至都不知道它的名字。