What would happen if you didnt sleep Claudia Aguirre

In 1965, 17-year-old high school student,
Randy Gardner

stayed awake for 264 hours.

That’s 11 days to see how
he’d cope without sleep.

On the second day,
his eyes stopped focusing.

Next, he lost the ability
to identify objects by touch.

By day three, Gardner was moody
and uncoordinated.

At the end of the experiment,
he was struggling to concentrate,

had trouble with short-term memory,

became paranoid,

and started hallucinating.

Although Gardner recovered without
long-term psychological

or physical damage,

for others, losing shuteye can result
in hormonal imbalance,

illness,

and, in extreme cases, death.

We’re only beginning to understand
why we sleep to begin with,

but we do know it’s essential.

Adults need seven to eight hours
of sleep a night,

and adolescents need about ten.

We grow sleepy due to signals
from our body

telling our brain we are tired,

and signals from the environment
telling us it’s dark outside.

The rise in sleep-inducing chemicals,

like adenosine and melatonin,

send us into a light doze
that grows deeper,

making our breathing
and heart rate slow down

and our muscles relax.

This non-REM sleep is when DNA is repaired

and our bodies replenish themselves
for the day ahead.

In the United States,

it’s estimated that 30% of adults
and 66% of adolescents

are regularly sleep-deprived.

This isn’t just a minor inconvenience.

Staying awake can cause
serious bodily harm.

When we lose sleep,

learning,

memory,

mood,

and reaction time are affected.

Sleeplessness may also cause inflammation,

halluciations,

high blood pressure,

and it’s even been linked
to diabetes and obesity.

In 2014, a devoted soccer fan died

after staying awake for 48 hours
to watch the World Cup.

While his untimely death
was due to a stroke,

studies show that chronically sleeping
fewer than six hours a night

increases stroke risk
by four and half times

compared to those getting a consistent
seven to eight hours of shuteye.

For a handful of people on the planet who
carry a rare inherited genetic mutation,

sleeplessness is a daily reality.

This condition,
known as Fatal Familial Insomnia,

places the body in a nightmarish
state of wakefulness,

forbidding it from entering
the sanctuary of sleep.

Within months or years,

this progressively worsening condition
leads to dementia and death.

How can sleep deprivation
cause such immense suffering?

Scientists think the answer lies
with the accumulation of waste prducts

in the brain.

During our waking hours,

our cells are busy using up
our day’s energy sources,

which get broken down
into various byproducts,

including adenosine.

As adenosine builds up,

it increases the urge to sleep,
also known as sleep pressure.

In fact, caffeine works by blocking
adenosine’s receptor pathways.

Other waste products
also build up in the brain,

and if they’re not cleared away,
they collectively overload the brain

and are thought to lead to the many
negative symptoms of sleep deprivation.

So, what’s happening in our brain
when we sleep to prevent this?

Scientists found something called
the glymphatic system,

a clean-up mechanism
that removes this buildup

and is much more active when we’re asleep.

It works by using cerebrospinal fluid
to flush away toxic byproducts

that accumulate between cells.

Lymphatic vessels,
which serve as pathways for immune cells,

have recently been discovered
in the brain,

and they may also play a role in clearing
out the brain’s daily waste products.

While scientists continue exploring
the restorative mechanisms behind sleep,

we can be sure that slipping
into slumber is a necessity

if we want to maintain our health
and our sanity.

1965 年,17 岁的高中生
兰迪·加德纳

264 小时不眠不休。

那是 11 天,看看
他如何在不睡觉的情况下应付。

第二天,
他的眼睛不再聚焦。

接下来,他失去了
通过触摸识别物体的能力。

到第三天,加德纳情绪低落
,不协调。

在实验结束时
,他难以集中注意力

,短期记忆出现问题,

变得偏执,

并开始产生幻觉。

尽管加德纳在没有
长期心理

或身体损伤的情况下康复,但

对其他人来说,失去闭眼会
导致荷尔蒙失调、

疾病

,在极端情况下甚至会导致死亡。

我们才刚刚开始了解
我们为什么要睡觉,

但我们确实知道这是必不可少的。

成年人每晚需要七到八个小时
的睡眠

,青少年需要大约十个小时。

我们会因为身体发出的信号

告诉我们的大脑我们累了,

以及来自环境的信号
告诉我们外面很黑而变得困倦。

诱导睡眠的化学物质(

如腺苷和褪黑激素)的增加

使我们进入打瞌睡状态
,变得更深,

使我们的呼吸
和心率减慢

,肌肉放松。

这种非快速眼动睡眠是 DNA 得到修复

并且我们的身体
为未来一天补充能量的时候。

在美国,

据估计 30% 的成年人
和 66% 的青少年

经常睡眠不足。

这不仅仅是一个小小的不便。

保持清醒会导致
严重的身体伤害。

当我们失眠时,

学习、

记忆、

情绪

和反应时间都会受到影响。

失眠还可能导致炎症、

幻觉、

高血压,

甚至
与糖尿病和肥胖有关。

2014 年,一位忠实的足球迷

在 48 小时不眠不休
观看世界杯后去世。

虽然他的英年早逝
是由于中风,但

研究表明,与持续睡眠 7 到 8 小时的人相比,长期
每晚睡眠不足 6 小时

会使中风风险
增加 4 倍

半。

对于地球上少数
携带罕见遗传基因突变的人来说,

失眠是每天的现实。

这种情况
被称为致命的家族性失眠症,

使身体处于噩梦般
的清醒状态,

禁止它进入
睡眠的庇护所。

在数月或数年内,

这种逐渐恶化的状况
会导致痴呆和死亡。

睡眠不足怎么会
造成如此巨大的痛苦?

科学家认为答案在于大脑
中废物的积累

在我们醒着的时候,

我们的细胞忙于消耗
我们一天的能量来源,

这些能量被分解
成各种副产品,

包括腺苷。

随着腺苷的积累,

它会增加睡眠的冲动,
也称为睡眠压力。

事实上,咖啡因通过阻断
腺苷的受体途径起作用。

其他废物
也会在大脑中积聚

,如果不清除它们,
它们会共同使大脑超负荷,

并被认为会导致
睡眠不足的许多负面症状。

那么,当我们睡觉时,我们的大脑会发生什么
来防止这种情况发生呢?

科学家们发现了一种
叫做 glymphatic 系统的东西,这

是一种清理机制
,可以清除这种堆积物,

并且在我们睡觉时更加活跃。

它通过使用
脑脊液冲走

细胞之间积聚的有毒副产物来发挥作用。

作为免疫细胞通路的淋巴管

最近
在大脑中被发现

,它们也可能在
清除大脑日常废物方面发挥作用。

虽然科学家们继续探索
睡眠背后的恢复机制,

但我们可以肯定,如果我们想保持健康和理智,
进入睡眠状态是必要的