Translate Science. Control The Narrative.

[Music]

trust the scientists

trust what the scientists are saying

that’s something we’ve all probably been

hearing recently or have at least heard

before

and i want to raise a counter question

and simply ask what if we don’t really

understand what the scientists are

saying

you see scientists have a communication

problem

their work is specialized so specialized

in fact that if a layperson were to go

about reading scientific reports as they

come out in academic journals

the chances are they won’t have a single

clue what these studies are talking

about

there’s an immense amount of jargon and

technical information tied up in graphs

and data

which require advanced knowledge to

fully understand

these articles are written for and by

other scientists in the field

and scientists in different fields say

astrophysics or neuroscience

don’t even know what the other one is

really talking about either

thus while there is genuinely exciting

research taking place in top

laboratories around the country most of

it happens behind closed doors

i know this first hand because i worked

in academia and i worked previously as a

scientist

but years ago when i was a humble

teenager before i had dreams of going

about science myself or

dropping whole-scale criticisms on

institutions of higher learning

i was volunteering at an assisted living

facility for the elderly

and people with dementia such as

alzheimer’s disease when i was in high

school we had this requirement about

community service

to get out of your orbit meet and

interact with different people and

do some good and that was cool and as a

teenager

what i really wanted to do was play

music all day so whenever the time came

to do some community service

i combined passion and obligation pick

up my guitar

and drive across town and play music at

an assisted living facility

now i love old people and already being

somewhat of an old man in my teens

i enjoyed spending long hours at the

nursing home listening to their stories

looking at pictures and singing songs

and there was one sunny afternoon there

where we’d been gathered around the

piano when one of the patients

a woman who because of her dementia

never said much to anyone

she’d smile and would talk and would

mostly repeat the same sentence like

clockwork

but this afternoon after i played some

songs on the piano

she said that she played piano growing

up and asked if she could play a piece

of music and i said absolutely

and she sat down and she played a

beautiful piece of music

far more complex than anything that i

could play but when the song was over it

was like it never happened

she was silent again she would repeat

the same sentence

the moment had passed and she had

forgotten

what makes it such that someone can

remember a beautiful arrangement on the

piano years later

but is unable to recall the conversation

or moment that happened a few minutes

before

that’s the question that got me

interested in science but here’s the

tough truth

we are all brought into science as

outsiders

and as i quickly learned that passion

notwithstanding

i had no idea what i was talking about i

knew nothing about anything

even after majoring in chemistry in

college and taking advanced biology

classes and working in a research lab

i was stunned when it came to studying

the brain

here’s a sample from a paper i was

reading at the time it’s a particularly

important paper published in nature

genetics

towards the beginning of the paper they

describe what they do

under the banner of the international

genomics of alzheimer’s project

we conducted a meta-analysis of four

g-wash samples of european ancestry

totaling over 17 08 cases and 37

154 controls in stage one followed up by

genotyping of 11

632 snips showing moderate evidence of

association p

less than 1 times 10 to the negative 3

in stage 1 in an independent sample that

included 8

572 cases and 11 312 controls in stage

in other words understanding the genetic

basis of alzheimer’s disease was going

to be

way more complicated way more difficult

to manage than the feeling of

inspiration that i got from a touching

moment that i experienced at a nursing

home

now people brand this inevitable lack of

knowledge at the beginning of one’s

graduate studies as a steep

learning curve now despite my lack of

knowledge on the topic

i knew enough to know that i wanted to

learn more and

i knew that i wanted to do better to

communicate my discoveries on paper in a

way that everyone could understand

so i read and i studied and i worked and

years went on and i found myself having

more experience

more familiarity and more confidence

with the work i was doing in the

laboratory

and after years of late nights at the

microscope and long experiments at the

bench

i finished and i put out my paper and i

had my phd

so i’m going to read you a line from my

paper

literally the punch line the big moment

what the research is

all about

we find that dorsal root ganglia and drg

axon secrete a factor supporting axon

girth and identify it as the c-terminus

of the er stress-induced transcription

factor kreb302 which is generated by

cytoprotease

cleavage and sensory neurons now

c-terminal crab302 forms a complex with

sonic hedgehock and stabilizes

association with the patch-1 receptor

and developing axons

our results reveal a neuron intrinsic

pathway downstream of sdp that promotes

axon growth

what no one knows what that means most

people don’t even know what these

proteins are and frankly these people

could be working

one biological inch away from the

sensory neurons that i was studying

so i didn’t beat the system and i didn’t

change the system

my own research was dense and unreadable

and it is here

that i am reminded of the first lesson

that kicked off this talk

science is hard

when i began speaking today i started

with the observation that academic

papers are tough to read and that

frankly they’re inaccessible for most

people

and i’m telling you now yep

that is the case we have specialized

problems

and we have specialized answers and it

can all be movie magic

and i don’t have the golden solution

here but i’m going to wager from my

experience

that one can constructively address this

problem

that is we can still improve scientific

communication

maybe targeting the journals is just the

wrong spot to do it

here are some possible solutions there

could be a requirement

say by high schools colleges and other

institutions of higher education

to teach classes that show how to

communicate science effectively

you can build communication into the

curriculum and really ask

what did this study say to you to guide

your experiments and understanding of

the field

and what does it mean for an outsider

every paper

every study focus on the main takeaways

do this in classes

in journal clubs and continue doing this

in academic publications

because some academic journals have in

fact developed a feature that paints

what the study is about in broad

brushstrokes

this puts scientists at the narrative

helm of their own work

they control the story and can prevent

it from being misinterpreted and

misunderstood

to quote my dad you could be the

smartest person in the entire world

but if you can’t get your ideas out in a

way that someone else can understand or

use them

then it doesn’t matter what you know you

can only live in your own head

as an academic community how do we get

outside of our own heads

and make sure that science gets

translated effectively

i want to give two easy pointers about

what people can do to communicate

science more effectively

number one never lose sight of what you

want to say translation

from one language to another takes many

forms let’s say you take a

story from ancient rome and translate it

in a way that completely misses the

poetry and only captures the prose

similarly you could miss the mark and

get so caught up in descriptions of

battle scenes that you totally left out

the emotional and narrative backdrop

before you communicate science you want

to identify the translation that you

were trying to make

number two stick to the main points my

old advisor would often point out that

young trainees would give talks about

their research and spend precious time

pouring over all the technical stuff

and by the end of the talk they would

forget to explain why they ever did what

they were doing in the first place

these speakers focused so much on the

how they for completely forgot the

points of the why

and what the heck does this even mean

when communicating their work

especially to the public scientists must

be able to explain

in a balanced way what they did how they

did it

why they did it and what it all means

so why am i saying all of this because

you should expect in fact

as a member of the public that these

needs are being met by the scientists to

explain things to you

you might not know or fully understand

the data at the end of the day

but you can and should know what to look

for when you read or hear about someone

else’s research

i want to talk about why this matters

why effective science communication is

important

at this point the kova 19 pandemic has

killed over 2 million people globally

and continues to mutate into dangerous

strains and yet there’s an excellent

technology

that could stop this virus straight in

its tracks and we’ve had it for decades

and it’s called a vaccine we know this

and at this moment across the u.s people

are being vaccinated with pfizer and

madarina vaccines that could bring us

out of this pandemic by neutralizing the

deadly effects of the virus

but that progress has been hampered by

rampant vaccine skepticism

in fact a poll from ap news reported as

recently as

early february 2021 that around one in

three u.s adults are skeptical about

receiving these fully

vetted vaccines one problem was that the

vaccine almost immediately became

political

as leading figures on both sides of the

aisle took shots of whether they would

take it

and numerous videos spread falsely

claiming that the vaccine was

ineffective or harmful or would even

change your dna

the longer the time has gone on medical

centers pharmaceutical companies

and other institutions have taken great

pains to explain how the vaccine works

but the stories and skepticism have

already run amok and a lot of damage has

been done

this was poor scientific communication

at its peak

not just by the scientists themselves

but by the journalists and politicians

who capitalized on a sensational moment

for their own gain

this is a failure in scientific

communication it also illustrates that

if you’re working on important research

how important it is to take your work

into your own hands and control the

narrative

otherwise someone else will

to close we do have to trust one another

we do have to trust the scientists but

we also have to be vigilant because

scientists are people too

and they make errors and they have

motives we have to accept the

limitations of our own knowledge and

leave some things in the hands

of the experts as difficult as that can

be whether it’s the details of a paper

about the molecular underpinnings of

dementia

or the release of a fully vetted vaccine

yet at the same time we all deserve to

know what goes on behind the closed

doors of a lab

research is funded by the government

which means your taxes

or your parents taxes go towards funding

research

you deserve to know what your money is

going towards

i think translating science effectively

is a force for unity

it brings us together as a practice it

keeps the public abreast of how the

frontiers of knowledge expand

every day as a scientist good

communication keeps you focused on the

big picture

what is this really about what are the

real world implications of my work

now personally i have both failed and

succeeded

at scientific communication but the

constant dialogue between failure and

success is also what science is all

about

we must embrace it accept it and use it

to grow to move on to discover even

better things

and then we must take care to explain in

a balanced way

what we did how we did it why we did it

and what it means thank you

[音乐]

相信科学家们

相信科学家们

所说的话,这可能是我们最近都

听过或至少

以前听过的东西

,我想提出一个

反问,如果我们不真正

理解科学家们的话怎么办 是

你看到科学家有沟通

问题

他们的工作非常专业

,事实上,如果一个外行人在学术期刊上发表

科学报告时去阅读科学报告,

他们很可能根本不

知道这些研究是什么 谈论

图表

和数据

中包含大量行话和技术信息,需要先进的知识

才能完全理解 另一个人

真正在谈论什么

全国各地的实验室大部分

都在闭门造车

我知道这是第一手资料,因为我曾

在学术界工作,以前我曾是一名

科学家,

但几年前,当我还是一个谦逊的

少年时,我还梦想着

自己从事科学工作或

放弃整个- 对

高等教育机构的大规模批评

当我在高中时,我在一家为老年人和患有痴呆症(如阿尔茨海默病)的人提供的辅助生活设施中做志愿者,

我们对社区服务有这样的要求,

以摆脱你的轨道

与不同的人见面并互动 人,

做一些好事,这很酷,

十几岁的时候

,我真正想做的就是

整天演奏音乐,所以每当

需要做一些社区服务时,

我将热情和义务结合起来,

拿起我的吉他

,开车穿过城镇,演奏音乐 现在在

辅助生活设施中,

我爱老人,并且

在我十几岁的时候已经有点像老人了,

我喜欢在这度过很长时间

疗养院听着他们的故事,

看着照片,唱歌

,那里有一个阳光明媚的下午

,我们聚集在

钢琴旁,其中一位患者

是一位因痴呆症而

从不对任何人说太多

她会微笑的人 并且会说话并且会

像发条一样重复同样的句子

但是今天下午我在钢琴上弹了一些歌曲后

她说她弹钢琴

长大并问她是否可以弹奏

一段音乐我说绝对

然后她坐下来 她演奏了一首

美妙的音乐,

比我

能演奏的任何曲子都复杂得多,但是当歌曲结束

时,就像从未发生

过一样

有人可以

记得几年后钢琴上的美妙编曲,

但无法回忆起

几分钟前发生的对话或时刻,

这就是问题 让我

对科学产生了兴趣,但这是一个

残酷的事实,

我们都被作为局外人带入科学领域

,因为我很快了解到这种热情

尽管

我不知道我在说

什么,但

即使在大学主修化学

并获得高级学位后,我对任何事情都一无所知 生物学

课和在研究实验室工作

当谈到研究大脑时,我惊呆了 这是

我当时正在阅读的一篇论文的样本

这是

一篇在自然遗传学上发表的特别重要的论文

,在论文的开头他们

描述了他们的工作

阿尔茨海默氏症项目的国际基因组学的旗帜下,

我们在第一阶段对四个

欧洲血统的 g-wash 样本进行了荟萃分析,

总计超过 17 08 个病例和 37

154 名对照,随后

对 11 632 个片段进行了基因分型,

显示出适度的

关联证据 在包括 8 572 例和 11 312 例的独立样本中,p

小于 1 乘以 10 到第 1 阶段的负 3

第 2 阶段的控制。

换句话说,了解

阿尔茨海默病的遗传基础将比

我在疗养院经历的一个感人时刻所获得的灵感要复杂得多,也更难管理

在研究生学习开始时不可避免地缺乏知识,

尽管我对该主题缺乏知识,但现在学习曲线

陡峭 以

一种每个人都能理解的方式发表论文,

所以我阅读、学习、工作,

多年过去了,我发现自己对我在实验室所做的工作有了

更多的经验,

更熟悉和更有信心

,在

经历了多年的深夜之后

显微镜和

长凳上的

长时间实验

我们发现背根神经节和 drg

轴突分泌一个支持轴突周长的因子,

并将其鉴定

为 er 应激诱导的转录

因子 kreb302 的 c 端,该因子由

细胞

蛋白酶切割和感觉产生 神经元现在

c-末端crab302与声波刺猬形成复合物

并稳定

与patch-1受体

和发育中的轴突的关联

我们的结果揭示了

sdp下游的神经元内在途径促进

轴突

生长没人知道这意味着大多数

人不知道 甚至知道这些

蛋白质是什么,坦率地说,这些人

可能在

距离

我正在研究的感觉神经元一英寸远的地方工作,

所以我没有击败系统,我没有

改变系统

我自己的研究是密集且难以理解

的 是

不是让我想起了开始这个谈话的第一节课

当我今天开始演讲时,科学很难,我

从观察开始 t

学术论文很难阅读,

坦率地说,它们对大多数人来说是无法访问的

,我现在告诉你

,是的,我们有专门的

问题

,我们有专门的答案,这

一切都可能是电影魔术

,我没有 这里有黄金解决方案

,但我会根据我的

经验

打赌,一个人可以建设性地解决这个

问题

,即我们仍然可以改善科学

交流,

也许瞄准期刊只是

错误的地方,

这里有一些可能的解决方案

高中、大学和其他

高等教育机构

要求教授课程以展示如何

有效地交流科学

你可以在课程中建立交流,

并真正

询问这项研究对你说了什么来指导

你的实验和

对该领域的理解

和 对局外人意味着什么

每篇论文

每篇研究都关注主要内容

在期刊俱乐部的课堂上这样做并继续 doi

在学术出版物中这样做

是因为一些学术期刊

实际上已经开发了一种功能,

可以粗略地描绘研究的内容

引用我爸爸的话,你可能

是全世界最聪明的人,

但如果你不能以

别人可以理解或使用的方式表达你的想法,

那么你知道什么都没关系,你

只能活在自己的世界里

作为一个学术界

的负责人,我们如何摆脱自己的头脑

并确保科学得到

有效翻译

我想给出两个简单的指示,

说明人们可以做些什么来

更有效地传播科学

第一,永远不要忘记你

想说的话

从一种语言到另一种语言的翻译有

多种形式,假设您

从古罗马取一个故事,并

以一种完全忽略了

诗歌和 只捕捉散文

同样你可能会错过标记并被

战斗场景的描述所吸引,以至于在你传达科学之前你完全忽略

了情感和叙事背景

想要确定

你试图让

第二个坚持的翻译 要点 我的

老导师经常会指出,

年轻的学员会就

他们的研究发表演讲,并花费宝贵的时间

倾注所有的技术内容

,而在演讲结束时,他们会

忘记解释为什么他们曾经做过

他们正在做的事情 首先,

这些演讲者非常关注

他们如何完全

忘记了原因

以及这到底意味着什么,

尤其是在向公众传达他们的工作时,科学家们

必须能够

以平衡的方式解释他们做了什么 他们

这样做了

为什么他们这样做以及这一切意味着什么

所以我为什么要说所有这些因为

您实际上应该期望

作为公众的一员 c

科学家们正在满足这些需求,以便

向您解释

您在一天结束时可能不知道或完全

理解数据的事情,

但是

当您阅读或听到别人的研究时,您可以而且应该知道要寻找什么

i 想谈谈为什么这很重要

为什么在这一点上有效的科学传播很

重要

kova 19 大流行已

在全球造成超过 200 万人死亡,

并继续变异为危险

毒株,但有一项出色的

技术可以直接阻止这种病毒的传播

我们已经使用了几十年

,它被称为疫苗,我们知道这

一点,此时此刻,美国各地的人们

都在接种辉瑞和

madarina 疫苗,这可以

通过中和病毒的致命影响使我们摆脱这场大流行,

但这一进展 一直受到

猖獗的疫苗怀疑论

的阻碍,事实上,美联社新闻的一项民意调查报告称

早在 2021 年 2 月上旬,大约有

三分之一的美国成年人 对

接受这些经过全面

审查的疫苗持怀疑态度 一个问题是

疫苗几乎立即成为

政治性的,

因为过道两边的主要人物都

拍摄了他们是否会

接受它,

并且大量视频传播错误地

声称该疫苗

无效或有害或会 甚至

改变你的

DNA 时间越长医疗

中心制药公司

和其他机构已经

煞费苦心地解释疫苗是如何工作的,

但故事和怀疑

已经肆虐,并且已经造成了很多损害

这是糟糕的科学沟通

在巅峰时期,

不仅是科学家自己

,还有记者和政治家

,他们利用耸人听闻的时刻

谋取私利

您的工作

掌握在自己手中,并控制

叙述,

否则某人 e else

will be close 我们确实必须相互信任

我们确实必须信任科学家,但

我们也必须保持警惕,因为

科学家也是人

,他们会犯错误,他们有

动机 我们必须接受

我们自己知识的局限性和

把一些事情

交给专家处理,

无论是关于痴呆症分子基础的论文的细节

还是经过全面审查的疫苗的发布,

但同时我们都应该

知道背后发生了什么

关闭的实验室

研究由政府资助,

这意味着您的税收

或您父母的税收用于资助

研究

您应该知道您的钱

将用于什么

我认为有效地翻译科学

是一种团结的力量

它将我们团结在一起 实践它

让公众了解知识的前沿如何

作为一名科学家每天都在扩展良好的

沟通让你专注于

全局这是什么

关于我的工作对现实世界的影响

现在我个人在科学交流方面既失败又

成功

,但

失败和成功之间的不断对话

也是科学的意义所在

我们必须接受它,接受它并利用它

来成长 继续发现

更好的东西

,然后我们必须注意

以平衡的方式解释

我们做了什么我们怎么做我们为什么这样做

以及这意味着什么谢谢